Author/Authors :
Haruhiko Fuwa، نويسنده , , Kenichi Hiromoto، نويسنده , , Yasuko Takahashi، نويسنده , , Satoshi Yokoshima، نويسنده , , Toshiyuki Kan، نويسنده , , Tohru Fukuyama، نويسنده , , Takeshi Iwatsubo، نويسنده , , Taisuke Tomita، نويسنده , , Hideaki Natsugari، نويسنده ,
Abstract :
Synthesis and biological evaluation of an arylsulfonamide class of γ-secretase inhibitors are described. Design, synthesis, and biological evaluation of multifunctional molecular probes harboring a benzophenone photophore as a cross-linking group and a biotin tag are also reported.
Keywords :
Photoaffinity probes , ?-Secretase inhibitors , structure–activity relationships , Arylsulfonamides
