Author/Authors :
Sanjay K. Srivastava، نويسنده , , Aji Abraham، نويسنده , , Beena Bhat، نويسنده , , Manu Jaggi، نويسنده , , Anu T. Singh، نويسنده , , Vinod K. Sanna، نويسنده , , Amit Chhabra and Gurvinder Singh، نويسنده , , Shiv K. Agarwal، نويسنده , , Rama Mukherjee، نويسنده , , Anand C. Burman، نويسنده ,
Abstract :
A number of costunolide derivatives (4a–p) have been synthesized and evaluated for their in vitro cytotoxicity against eight tumor and a non-tumor cell lines. Compound 4d showed around 2-fold better cytotoxicity against SW-620 (colon) cell line with improved safety index than costunolide (1). While compounds 4e, 4g, and 4p have shown around 2- to 3-fold better cytotoxicity against MIAPaCa2 (pancreas), K-562 (leukemia) and PA-1 (ovary) cell lines as well as better safety index in comparison to costunolide (1). Compound 4p also exhibited cytotoxicity against HBL100 (breast) cell line with 2-fold better safety index. Structure–activity relationship has been described.
