Title of article
Antiproliferation and apoptosis induced by C-glycosides in human leukemia cancer cells
Author/Authors
Carlos A. Sanhueza، نويسنده , , Carlos Mayato، نويسنده , , Mar?a Garc?a-Chicano، نويسنده , , Raquel D?az-Pe?ate، نويسنده , , Rosa L. Dorta، نويسنده , , Jes?s T. V?zquez، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
4223
To page
4227
Abstract
A large series of alkyl C-glycosides was synthesized from d-glucal or d-galactal. These compounds were screened against the human promyelocytic leukemia cell line (HL60), showing significant activity and apoptosis. Up to 13 C-glucopyranosides, but no C-galacto- or C-mannopyranosides, exhibited inhibitory concentrations (IC50 values) below 20 μM, five of them in the range 4–8 μM. Preliminary structure–activity relationships were established.
Keywords
C-Glycosides , Leukemia (HL60) , Apoptosis , cancer
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797166
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