Title of article
Design and synthesis of potent, non-peptidic inhibitors of HPTPβ
Author/Authors
Kande K.D. Amarasinghe، نويسنده , , Artem G. Evidokimov، نويسنده , , Kevin Xu، نويسنده , , Cynthia M. Clark، نويسنده , , Matthew B. Maier، نويسنده , , Anil Srivastava، نويسنده , , Anny-Odile Colson، نويسنده , , Gina S. Gerwe، نويسنده , , George E. Stake، نويسنده , , Brian W. Howard، نويسنده , , Matthew E. Pokross، نويسنده , , Jeffrey L. Gray، نويسنده , , Kevin G. Peters، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
4252
To page
4256
Abstract
The sulfamic acid phosphotyrosine mimetic was coupled with a previously known malonate template to obtain highly selective and potent inhibitors of HPTPβ. Potentially hydrolyzable malonate ester functionalities were replaced with 1,2,4-oxadiazoles without a significant effect on HPTPβ potency.
Keywords
protein tyrosine phosphatases , HPTP? , malonates , sulfamic acid , Oxadiazoles
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797172
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