Title of article
Design and synthesis of tetracyclic nonpeptidic biaryl nitrile inhibitors of cathepsin K
Author/Authors
Eduardo L. Setti، نويسنده , , Shankar Venkatraman، نويسنده , , James T. Palmer، نويسنده , , Xiaoming Xie، نويسنده , , Harry Cheung، نويسنده , , Walter Yu، نويسنده , , Gregg Wesolowski، نويسنده , , Joël Robichaud، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
4296
To page
4299
Abstract
The synthesis and biological profile of a novel series of potent and selective inhibitors of cysteine protease cathepsin K (Cat K) are described. Pharmacokinetic evaluation of 12 indicated that some members of this series could be suitable candidates to develop new orally active therapeutic agents for the treatment of osteoporosis.
Keywords
Cathepsin K inhibitors , Nonpeptidic biaryl nitriles
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797181
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