Title of article
3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists: Part 1
Author/Authors
Robert Epple، نويسنده , , Ross Russo، نويسنده , , Mihai Azimioara، نويسنده , , Christopher Cow، نويسنده , , Yongping Xie، نويسنده , , Xing Wang، نويسنده , , John Wityak، نويسنده , , Don Karanewsky، نويسنده , , Andrea Gerken، نويسنده , , Maya Iskandar، نويسنده , , Enrique Saez، نويسنده , , H. Martin Seidel، نويسنده , , Shin-Shay Tian، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
4376
To page
4380
Abstract
We report the identification of a novel series of trisubstituted isoxazoles as PPAR activators from a high-throughput screen. A series of structural optimizations led to improved efficacy and excellent functional receptor selectivity for PPARδ. The isoxazoles represent a series of agonists which display a scaffold that lies outside the typical PPAR agonist motif.
Keywords
PPAR? agonists , Energy homeostasis , isoxazoles , metabolic syndrome
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797196
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