Title of article :
Metabolism investigation leading to novel drug design 2: Orally active prostacyclin mimetics. Part 5
Author/Authors :
Fujiko Takamura، نويسنده , , Akira Tanaka، نويسنده , , Hisashi Takasugi، نويسنده , , Kiyoshi Taniguchi، نويسنده , , Mie Nishio، نويسنده , , Jiro Seki، نويسنده , , Kouji Hattori، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
A metabolism study of FK788 (2) led to the discovery of new diphenylcarbamoyl derivatives as prostacyclin mimetics without the PG skeleton. We designed and evaluated PGI2 mimetics based on blocking the main metabolic pathway of FK788. The new compound 7c was found to be equipotent to FK788 towards PGI2 agonist activity and metabolically more stable than FK788.
Keywords :
Prostacyclin , FK788 , PG , PGI2 , metabolism
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
