Title of article :
Development of first photoresponsive prodrug of paclitaxel
Author/Authors :
Mariusz Skwarczynski، نويسنده , , Mayo Noguchi، نويسنده , , Shun Hirota، نويسنده , , Youhei Sohma، نويسنده , , Tooru Kimura، نويسنده , , Yoshio Hayashi، نويسنده , , Yoshiaki Kiso، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
A prodrug of paclitaxel which has a coumarin derivative conjugated to the amino acid moiety of isotaxel (O-acyl isoform of paclitaxel) has been synthesized. The prodrug was selectively converted to isotaxel by visible light irradiation (430 nm) with the cleavage of coumarin. Finally, paclitaxel was released by subsequent spontaneous O–N intramolecular acyl migration.
Keywords :
taxol , Photoresponsive , Tumor targeting prodrug , O–N intramolecular acyl migration , coumarin , Visible light irradiation
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
