Title of article
Studies towards the conception of new selective PPARβ/δ ligands
Author/Authors
Carine Ekambomé Basséne، نويسنده , , Franck Suzenet، نويسنده , , Nathalie Hennuyer، نويسنده , , Bart Staels، نويسنده , , Daniel-Henri Caignard، نويسنده , , Catherine Dacquet، نويسنده , , Pierre Renard، نويسنده , , Gérald Guillaumet، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
4528
To page
4532
Abstract
In order to define new PPARβ/δ ligands, SAR study on the selective PPARβ/δ activator L-165,041 led to the identification of one key functional group for selective PPARβ/δ activation. Furthermore, taking advantage of SAR studies done elsewhere on the most selective PPARβ/δ ligand GW501516, the conception of new ligands showing good affinity for PPARβ/δ is reported. Finally, synthesis and biological evaluation of pyridine analogues have shown the benefical effect of the pyridine ring on the PPARβ/δ subtype selectivity.
Keywords
PPAR?/? , pyridine , Nuclear receptor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797223
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