Title of article
Hydrazides of clozapine: A new class of D1 dopamine receptor subtype selective antagonists
Author/Authors
T.K. Sasikumar، نويسنده , , D.A. Burnett، نويسنده , , H. Zhang، نويسنده , , A. Smith-Torhan، نويسنده , , Amani A. Fawzi، نويسنده , , J.E. Lachowicz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
4543
To page
4547
Abstract
Acylated and aroylated hydrazinoclozapines are highly potent dopamine D1 antagonists that show remarkable selectivity over other dopamine receptors. The most potent compound in this series is the 2,6-dimethoxybenzhydrazide 33 with a D1Ki of 1.6 nM and 212-fold selectivity over D2 receptor.
Keywords
Hydrazinoclozapine , Dopamine D1 , Clozapine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797226
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