Title of article
Identification of novel pyrazole acid antagonists for the EP1 receptor
Author/Authors
Stephen C. McKeown، نويسنده , , Adrian Hall، نويسنده , , Gerard M.P. Giblin، نويسنده , , Olivier Lorthioir، نويسنده , , Richard Blunt، نويسنده , , Xiao Q. Lewell، نويسنده , , Richard J. Wilson، نويسنده , , Susan H. Brown، نويسنده , , Anita Chowdhury، نويسنده , , Tanya Coleman، نويسنده , , Stephen P. Watson، نويسنده , , Iain P. Chessell، نويسنده , , Adrian Pipe، نويسنده , , Nick Clayton، نويسنده , , Paul Goldsmith، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
4767
To page
4771
Abstract
The discovery, synthesis and structure–activity relationship (SAR) of a novel series of EP1 receptor antagonists is described. Pyrazole acid 4, identified from a chemical array, had desirable physicochemical properties, an excellent in vitro microsomal inhibition and cytochrome P450 (CYP450) profile and good exposure levels in blood. This compound had an ED50 of 1.3 mg/kg in a rat pain model. A range of more potent analogues in the in vitro assay was identified using efficient array chemistry. These EP1 antagonists have potential as agents in the treatment of PGE2 mediated pain.
Keywords
EP1 antagonist , Prostanoid , pain , Pyrazole
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797273
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