Title of article :
Synthesis of 2-amino-4-(7-azaindol-3-yl)pyrimidines as cyclin dependent kinase 1 (CDK1) inhibitors
Author/Authors :
Shenlin Huang، نويسنده , , Ronghua Li، نويسنده , , Peter J. Connolly، نويسنده , , Stuart Emanuel، نويسنده , , Steven A. Middleton، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
A novel series of 2-amino-4-(7-azaindol-3-yl)pyrimidines was discovered as cyclin dependent kinase 1 (CDK1) inhibitors. The core structure was synthesized via Pd(II) catalyzed coupling reaction. A number of analogues showed good potency for CDK1 and exhibited cellular antiproliferation activity. The structure–activity relationship is described.
Keywords :
2-Amino-4-(7-azaindol-3-yl)pyrimidine , CDK1
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
