Title of article
New spiro-piperidines as 5-HT2B receptor antagonists
Author/Authors
Hugues Bienaymé، نويسنده , , Laurent Chêne، نويسنده , , Serge Grisoni، نويسنده , , Antonio Grondin، نويسنده , , El-Bachir Kaloun، نويسنده , , Stéphane Poigny، نويسنده , , Houcine Rahali، نويسنده , , Eric Tam، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
4830
To page
4833
Abstract
A functional screening highlighted a series of spiro-piperidines as 5-HT2B receptor antagonists. Preliminary structure–activity relationship has been explored driving to potent antagonists (IC50 = 1 nM) and indicating directions for further explorations.
Keywords
G-protein coupled receptors , Pyrazoline , Spiro-piperidines , HTR2B antagonists
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797288
Link To Document