Title of article :
New spiro-piperidines as 5-HT2B receptor antagonists
Author/Authors :
Hugues Bienaymé، نويسنده , , Laurent Chêne، نويسنده , , Serge Grisoni، نويسنده , , Antonio Grondin، نويسنده , , El-Bachir Kaloun، نويسنده , , Stéphane Poigny، نويسنده , , Houcine Rahali، نويسنده , , Eric Tam، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
4
From page :
4830
To page :
4833
Abstract :
A functional screening highlighted a series of spiro-piperidines as 5-HT2B receptor antagonists. Preliminary structure–activity relationship has been explored driving to potent antagonists (IC50 = 1 nM) and indicating directions for further explorations.
Keywords :
G-protein coupled receptors , Pyrazoline , Spiro-piperidines , HTR2B antagonists
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2006
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
797288
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=797288
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