Author/Authors :
Akira Tanaka، نويسنده , , Kouji Hattori، نويسنده , , Kiyoshi Taniguchi، نويسنده , , Osamu Okitsu، نويسنده , , Seiichiro Tabuchi، نويسنده , , Mie Nishio، نويسنده , , Yasunori Nagakura، نويسنده , , Noriaki Maeda، نويسنده , , Hidetsugu Murai، نويسنده , , Jiro Seki، نويسنده ,
Abstract :
The synthesis and biological activity of novel derivatives of our previously reported IP receptor agonist FR181157 is described. SAR studies to replace the cyclohexene-linker of FR181157 led to the discovery of compound 1i (FR207845) as a potent non-prostanoid PGI2 mimetic with good oral bioavailability.
Keywords :
IP receptor , Prostacyclin , PGI2 , agonist
