Title of article :
Macrolactin N, a new peptide deformylase inhibitor produced by Bacillus subtilis
Author/Authors :
Jung-Sung Yoo، نويسنده , , Chang-Ji Zheng، نويسنده , , Sangku Lee، نويسنده , , Jin Hwan Kwak، نويسنده , , Won-Gon Kim، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
A new 24-membered ring lactone, macrolactin N, was isolated from a culture broth of Bacillus subtilis and its structure was established by various spectral analysis. Macrolactin N inhibited Staphylococcus aureus peptide deformylase with an IC50 value of 7.5 μM and also showed antibacterial activity against Escherichia coli and S. aureus.
Keywords :
Peptide deformylase , S. aureus , Macrolactin , Antibacterial
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
