Title of article
Structure–activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells
Author/Authors
Barnaby C.H. May، نويسنده , , Juanita Witkop، نويسنده , , John Sherrill، نويسنده , , Marc O. Anderson، نويسنده , , Peter B. Madrid، نويسنده , , Julie A. Zorn، نويسنده , , Stanley B. Prusiner، نويسنده , , Fred E. Cohen، نويسنده , , R. Kiplin Guy، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
4913
To page
4916
Abstract
A focused library of variously substituted 9-aminoacridine compounds was screened for bioactivity against accumulation of the infectious prion protein isoform, denoted PrPSc, in a cell model of prion replication. The efficacy of compounds against PrPSc accumulation was influenced by both substituents of the distal tertiary amine and acridine heterocycle, while cellular cytotoxicity was encoded in the acridine heterocycle substituents.
Keywords
Prion , PrPSc , PrPC , 9-Aminoacridine , Quinacrine , SCN2A , PRP
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797304
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