Author/Authors :
Zhao-Kui Wan، نويسنده , , Jinbo Lee، نويسنده , , Weixin Xu، نويسنده , , David V. Erbe، نويسنده , , Diane Joseph-McCarthy، نويسنده , , Bruce C. Follows، نويسنده , , Yanling Zhang، نويسنده ,
Abstract :
A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural information and computational modeling, rational design led to key interactions with Asp48 and improved inhibitory potency against PTP1B.
