Title of article
Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: Capturing interactions with Asp48
Author/Authors
Zhao-Kui Wan، نويسنده , , Jinbo Lee، نويسنده , , Weixin Xu، نويسنده , , David V. Erbe، نويسنده , , Diane Joseph-McCarthy، نويسنده , , Bruce C. Follows، نويسنده , , Yanling Zhang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
4941
To page
4945
Abstract
A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural information and computational modeling, rational design led to key interactions with Asp48 and improved inhibitory potency against PTP1B.
Keywords
Protein tyrosine phosphatase 1B (PTP1B)
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797309
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