Title of article :
Site-Selective DNA cleavage by a novel complex of copper-conjugate of Phen and polyamide containing N-methylimidazole rings
Author/Authors :
Dan Liu، نويسنده , , Jiang Zhou، نويسنده , , Huihui Li، نويسنده , , Bo Zheng، نويسنده , , Gu Yuan، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
A novel conjugate of 3-Clip-Phen and polyamide containing three N-methylimidazole (Im) rings was synthesized for the targeting human telomeric repeat of 5′-TTAGGG-3′, and the DNA cleaving activity and the sequence selectivity of the complex of copper-conjugate were confirmed by electrospray ionization mass spectrometry.
Keywords :
ESI-mass spectrometry , Site-selective DNA cleavage , DNA cleaving activity
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
