Title of article
Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide
Author/Authors
Iontcho R. Vlahov، نويسنده , , Hari Krishna R. Santhapuram، نويسنده , , Paul J. Kleindl، نويسنده , , Stephen J. Howard، نويسنده , , Katheryn M. Stanford، نويسنده , , Christopher P. Leamon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
5093
To page
5096
Abstract
An efficient synthesis of the folate receptor (FR) targeting conjugate EC145 is described. EC145 is a water soluble derivative of the vitamin folic acid and the potent cytotoxic agent, desacetylvinblastine monohydrazide. Both molecules are connected in regioselective manner via a hydrophilic peptide spacer and a reductively labile disulfide linker.
Keywords
Targeted therapeutics , Disulfide , Anti-cancer , folate , Desacetylvinblastine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797336
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