• Title of article

    Synthesis of 3H-spiro[benzofuran-2,1′-cyclohexane] derivatives from naturally occurring filifolinol and their classical complement pathway inhibitory activity

  • Author/Authors

    Mariana Useglio، نويسنده , , Patricia M. Castellano، نويسنده , , Mar?a A. Operto، نويسنده , , Rene Torres، نويسنده , , Teodoro S. Kaufman، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2006
  • Pages
    5
  • From page
    5097
  • To page
    5101
  • Abstract
    Six 3H-spiro[benzofuran-2,1′-cyclohexane] derivatives were synthesized from naturally occurring filifolinol, and their classical complement pathway inhibitory activity was determined. IC50 values of the most potent compounds were comparable to the activity of the natural complement inhibitor K76-COOH and some synthetic tricyclic analogs of it.
  • Keywords
    Filifolinol , 1?-cyclohexanes] , Analogs of K76 , Complement inhibition
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2006
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    797337

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=797337