Title of article :
Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa
Author/Authors :
Yun-Long Li، نويسنده , , John M. Fevig، نويسنده , , Joseph Cacciola، نويسنده , , Joseph Buriak Jr.، نويسنده , , Karen A. Rossi، نويسنده , , Janan Jona، نويسنده , , Robert M. Knabb، نويسنده , , Joseph M. Luettgen، نويسنده , , Pancras C. Wong، نويسنده , , Stephen A. Bai، نويسنده , , Ruth R. Wexler، نويسنده , , Patrick Y.S. Lam، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
Previously, potent factor Xa inhibitors were described based on the 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one bicyclic core and a 4-methoxyphenyl P1 moiety. This manuscript describes 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one and related bicyclic cores with the 3-aminobenzisoxazole P1 moiety. Many of these compounds are potent, selective, and efficacious inhibitors of coagulation factor Xa.
Keywords :
Anticoagulants , Factor Xa inhibitors , 3-d]pyrimidin-7(6H)-ones , Pyrazole , Bicyclic core , Antithrombotic agents
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
