Title of article
2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists
Author/Authors
Jinlong Jiang، نويسنده , , Myle Hoang، نويسنده , , Jonathan R. Young، نويسنده , , Danny Chaung، نويسنده , , Ronsar Eid، نويسنده , , Cherilyn Turner، نويسنده , , Peter Lin، نويسنده , , Xinchun Tong، نويسنده , , Junying Wang، نويسنده , , Carina Tan، نويسنده , , Scott Feighner، نويسنده , , Oksana Palyha، نويسنده , , Donna L. Hreniuk، نويسنده , , Jie Pan، نويسنده , , Andreas W. Sailer، نويسنده , , Douglas J. MacNeil، نويسنده , , Andrew Howard، نويسنده , , Lauren Shearman، نويسنده , , D. Sloan Stribling، نويسنده , , Ramon Camacho، نويسنده , , et al.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
5270
To page
5274
Abstract
A series of 2-aminoquinoline compounds was prepared and evaluated in MCH1R binding and functional antagonist assays. Small dialkyl, methylalkyl, methylcycloalkyl, and cyclic amines were tolerated at the quinoline 2-position. The in vivo efficacy of compound 12 was explored and compared to that of a related inactive analog to determine their effects on food intake and body weight in rodents.
Keywords
GPCR , Antagonist , Quinoline , Melanin-concentrating hormone , obesity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797368
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