Title of article
A dual lanthanide probe suitable for optical (Tb3+ luminescence) and magnetic resonance imaging (Gd3+ relaxometry)
Author/Authors
Claude Picard، نويسنده , , Neri Geum، نويسنده , , Isabelle Nasso، نويسنده , , Béatrice Mestre، نويسنده , , Pierre Tisnès، نويسنده , , Sophie Laurent، نويسنده , , Robert N. Muller، نويسنده , , Luce Vander Elst، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
5309
To page
5312
Abstract
A new polyaminocarboxylate ligand derived from N,C-pyrazolylpyridine was synthesized. The luminescence and relaxometry properties of its Tb3+ and Gd3+ chelates were investigated in aqueous solutions. The Tb3+ chelate is strongly luminescent having remarkable lifetime and quantum yield (τ = 1.82 ms and Φ = 0.42). The 1/T1 proton relaxivity at 20 MHz and 25 °C (5.3 s−1 mM−1) of the Gd3+ chelate was found to be comparable to that of the clinically used Gd-DTPA.
Keywords
N , C-Pyrazolylpyridine , luminescence , Lanthanide complexes , relaxometry
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797376
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