Title of article
Aza-stilbenes as potent and selective c-RAF inhibitors
Author/Authors
Octerloney McDonald، نويسنده , , Karen Lackey، نويسنده , , Ronda Davis-Ward، نويسنده , , Edgar Wood، نويسنده , , Vicente Samano، نويسنده , , Patrick Maloney، نويسنده , , Felix Deanda، نويسنده , , Robert Hunter، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
5378
To page
5383
Abstract
The synthesis of several novel aza-stilbene derivatives was carried out. The compounds were tested for their c-RAF enzyme inhibition. Compound 27 possesses significant potency against c-RAF and demonstrates selectivity over other protein kinases. A hypothesis for the binding mode, activity, and selectivity is proposed.
Keywords
kinase , c-RAF , Aza-stilbene
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797391
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