Title of article :
Synthesis and structural activity relationship of 11β-HSD1 inhibitors with novel adamantane replacements
Author/Authors :
Vince S.C. Yeh، نويسنده , , Ravi Kurukulasuriya، نويسنده , , David Madar، نويسنده , , Jyoti R. Patel، نويسنده , , Steven Fung، نويسنده , , Katina Monzon، نويسنده , , William Chiou، نويسنده , , Jiahong Wang، نويسنده , , Peer Jacobson، نويسنده , , Hing L. Sham، نويسنده , , J.T Link، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
6
From page :
5408
To page :
5413
Abstract :
A series of structurally novel and metabolically stable bridged bicyclic carbocycle and heterocycle adamantane replacements have been synthesized and biologically evaluated. Several of these compounds exhibit excellent human and mouse 11β-HSD1 potency and 11β-HSD2 selectivity.
Keywords :
11?-HSD1 , Adamantane replacements , Metabolic stability
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2006
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
797397
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=797397
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