Title of article
Synthesis and structural activity relationship of 11β-HSD1 inhibitors with novel adamantane replacements
Author/Authors
Vince S.C. Yeh، نويسنده , , Ravi Kurukulasuriya، نويسنده , , David Madar، نويسنده , , Jyoti R. Patel، نويسنده , , Steven Fung، نويسنده , , Katina Monzon، نويسنده , , William Chiou، نويسنده , , Jiahong Wang، نويسنده , , Peer Jacobson، نويسنده , , Hing L. Sham، نويسنده , , J.T Link، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
5408
To page
5413
Abstract
A series of structurally novel and metabolically stable bridged bicyclic carbocycle and heterocycle adamantane replacements have been synthesized and biologically evaluated. Several of these compounds exhibit excellent human and mouse 11β-HSD1 potency and 11β-HSD2 selectivity.
Keywords
11?-HSD1 , Adamantane replacements , Metabolic stability
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797397
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