Title of article :
Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases
Author/Authors :
T.K. Sasikumar، نويسنده , , Li Qiang، نويسنده , , Duane A. Burnett، نويسنده , , William J. Greenlee، نويسنده , , Brian E. Hawes، نويسنده , , Timothy J. Kowalski، نويسنده , , Kim O’Neill، نويسنده , , Brian D. Spar، نويسنده , , Blair Weig، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
5
From page :
5427
To page :
5431
Abstract :
A series of novel aminobenzimidazoles was prepared and evaluated for h-MCH-R1 antagonist properties. Most of the compounds showed excellent h-MCH-R1 binding affinity as well as mouse ex vivo binding. Compounds 9 and 18 were active in mouse DIO studies at 30 mpk.
Keywords :
Melanin-concentrating hormone , Aminobenzimidazoles , Metabolic diseases
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2006
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
797401
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=797401
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