Title of article
Antiprotozoal activities of new bis-chlorophenyl derivatives of bicyclic octanes and aza-nonanes
Author/Authors
Heinrich Berger، نويسنده , , Werner Seebacher، نويسنده , , Robert Saf، نويسنده , , Marcel Kaiser، نويسنده , , Reto Brun، نويسنده , , Robert Weis، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
5457
To page
5461
Abstract
The in vitro activity of newly synthesized bis-(chlorophenyl)-azabicyclo[3.2.2]nonanes and bis-(chlorophenyl)-bicyclo[2.2.2]octanes against Plasmodium falciparum K1 (resistant to chloroquine and pyrimethamine) and Trypanosoma brucei rhodesiense was investigated. Especially the bis-(chlorophenyl)-azabicyclo[3.2.2]nonanes exhibit promising antitrypanosomal activity and were tested in vivo against Trypanosoma brucei brucei featuring moderate activities.
Keywords
Antiplasmodial activity , Antitrypanosomal activity , Aza-bicyclononanes , In vitro and in vivo assays , Bicyclo-octanones
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797407
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