Author/Authors :
Namal C. Warshakoon، نويسنده , , Shengde Wu، نويسنده , , Angelique Boyer، نويسنده , , Richard Kawamoto، نويسنده , , Justin Sheville، نويسنده , , Sean Renock، نويسنده , , Kevin Xu، نويسنده , , Matthew Pokross، نويسنده , , Artem G. Evdokimov، نويسنده , , Richard Walter، نويسنده , , Marlene Mekel، نويسنده ,
Abstract :
Utilizing modeling information from a recently resolved structure of human HIF-1α prolyl hydroxylase (EGLN1) and structure-based design, a novel series of imidazo[1,2-a]pyridine derivatives was prepared. The activity of these compounds was determined in a human EGLN1 assay and a limited SAR was developed.
