Title of article
A bioisosteric approach to the discovery of indole carbinol androgen receptor ligands
Author/Authors
James C. Lanter، نويسنده , , James J. Fiordeliso، نويسنده , , George F. Allan، نويسنده , , Amy Musto، نويسنده , , Do Won Hahn، نويسنده , , Zhihua Sui، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
5646
To page
5649
Abstract
Two potential bioisosteres of the nonsteroidal antiandrogen bicalutamide, an imidazolidinone and an indole, were synthesized and tested for their androgen receptor binding. Indole was discovered to be a suitable bioisostere for the acyl anilide moiety in the parent compound. Several analogs in the indole series were found to be 10-fold better than bicalutamide in binding to the recombinant androgen receptor binding domain.
Keywords
Stilbene , Tyrosinase inhibitor , cytotoxicity , Oxyresveratrol
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797447
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