Title of article
Synthesis and HIV-integrase strand transfer inhibition activity of 7-hydroxy[1,3]thiazolo[5,4-b]pyridin-5(4H)-ones
Author/Authors
Eric E. Boros، نويسنده , , Brian A. Johns، نويسنده , , Edward P. Garvey، نويسنده , , Cecilia S. Koble، نويسنده , , Wayne H. Miller، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
5668
To page
5672
Abstract
An efficient synthesis of methyl 7-hydroxy[1,3]thiazolo[5,4-b]pyridin-5(4H)-one-6-carboxylates (8–10 and 16) and 6-carboxamides (17–20) is described. Sub-micromolar enzyme inhibition of HIV integrase was achieved with several carboxamide analogs which were superior to their carboxylic ester congeners.
Keywords
oxime , Acetylcholinesterase , reactivation , Nerve agent , Reactivator , paraoxon , tabun , pesticide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797452
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