Title of article
Inhibition of P-glycoprotein-mediated multidrug efflux by aminomethylene and ketomethylene analogs of reversins
Author/Authors
Ali Koubeissi، نويسنده , , Imad Raad، نويسنده , , Laurent Ettouati، نويسنده , , David Guilet، نويسنده , , Charles Dumontet، نويسنده , , Joelle Paris، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
5700
To page
5703
Abstract
Several aminomethylene analogs and a ketomethylene analog of reversins were synthesized in order to evaluate their ability to inhibit P-glycoprotein-mediated drug efflux in K562/R7 human leukemic cells overexpressing P-glycoprotein. These analogs retained good activity compared to cyclosporin A and the original reversins.
Keywords
Pseudopeptide , Chemosensitizer , P-glycoprotein , Reversin , Ketomethylene , Multidrug resistance , Aminomethylene
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797459
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