Title of article :
Inhibition of P-glycoprotein-mediated multidrug efflux by aminomethylene and ketomethylene analogs of reversins
Author/Authors :
Ali Koubeissi، نويسنده , , Imad Raad، نويسنده , , Laurent Ettouati، نويسنده , , David Guilet، نويسنده , , Charles Dumontet، نويسنده , , Joelle Paris، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
Several aminomethylene analogs and a ketomethylene analog of reversins were synthesized in order to evaluate their ability to inhibit P-glycoprotein-mediated drug efflux in K562/R7 human leukemic cells overexpressing P-glycoprotein. These analogs retained good activity compared to cyclosporin A and the original reversins.
Keywords :
Pseudopeptide , Chemosensitizer , P-glycoprotein , Reversin , Ketomethylene , Multidrug resistance , Aminomethylene
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
