Author/Authors :
Jun Oishi، نويسنده , , Moeko Ijuin، نويسنده , , Tatsuhiko Sonoda، نويسنده , , Jeong-Hun Kang، نويسنده , , By KENJI KAWAMURA، نويسنده , , Takeshi Mori، نويسنده , , Takuro Niidome، نويسنده , , Yoshiki Katayama، نويسنده ,
Abstract :
We have previously reported artificial gene-regulation systems responding to cyclic AMP-dependent protein kinase (PKA) using a cationic polymer. However, this polymer alone cannot deliver any gene into living cells. In the present work, we modified the signal-responsive polymer to the RGD peptide for the introduction of a polymer/DNA complex into living cells and succeeded in regulating the gene expression responding to intracellular PKA activation.
