Title of article :
Discovery and synthesis of tetrahydroindolone-derived carbamates as Kv1.5 blockers
Author/Authors :
Andrew Fluxe، نويسنده , , Shengde Wu، نويسنده , , James B. Sheffer، نويسنده , , John M. Janusz، نويسنده , , Michael Murawsky، نويسنده , , Gina M. Fadayel، نويسنده , , Bin Fang، نويسنده , , Michelle Hare، نويسنده , , Laurent Djandjighian، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
4
From page :
5855
To page :
5858
Abstract :
A novel class of tetrahydroindolone-derived carbamates has been discovered whose members are potent Kv1.5 blockers. The in vitro data show that compounds 6 and 29 are quite potent. They are also very selective over hERG (>450-fold) and L-type calcium channels (>450-fold).
Keywords :
Carbamate , Kv1.5 blocker , Atrial antiarrhythmic , In vitro efficacy
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2006
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
797489
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=797489
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