Author/Authors :
Mark Sabat، نويسنده , , John C. VanRens، نويسنده , , Matthew J. Laufersweiler، نويسنده , , Todd A. Brugel، نويسنده , , Jennifer Maier، نويسنده , , Adam Golebiowski، نويسنده , , Biswanath De، نويسنده , , Vijayasurian Easwaran، نويسنده , , Lily C. Hsieh، نويسنده , , Richard L. Walter and Alan M. Friedman، نويسنده , , Marlene J. Mekel، نويسنده , , Artem Evdokimov، نويسنده , , Michael J. Janusz، نويسنده ,
Abstract :
This communication details the synthesis, biological activity, and binding mode of a novel class of 2-benzimidazole substituted pyrimidines. The most potent analogs disclosed showed low nanomolar activity for the inhibition of Lck kinase and a representative analog was co-crystallized with Hck (a structurally related member of the Src family kinases).
Keywords :
Hck , Lymphocyte specific kinase , Src family kinase , T cell , kinase , Hematopoietic cell kinase , Lck
