Author/Authors :
Alice Lee-Dutra، نويسنده , , Kristen L. Arienti، نويسنده , , Daniel J. Buzard، نويسنده , , Michael D. Hack، نويسنده , , Haripada Khatuya، نويسنده , , Pragnya J. Desai، نويسنده , , Steven Nguyen، نويسنده , , Robin L. Thurmond، نويسنده , , Lars Karlsson، نويسنده , , James P. Edwards، نويسنده , , J. Guy Breitenbucher، نويسنده ,
Abstract :
A series of 2-arylbenzimidazoles was synthesized and found to bind with high affinity to the human histamine H4 receptor. Structure–activity relationships were investigated through library preparation and evaluation as well as traditional medicinal chemistry approaches, leading to the discovery of compounds with single-digit nanomolar affinity for the H4 receptor.
