Title of article
Identification and optimisation of 5-amino-7-aryldihydro-1,4-diazepines as 5-HT2A ligands
Author/Authors
Christopher J. Swain، نويسنده , , Ana Teran، نويسنده , , Marta Maroto، نويسنده , , Angeles Cabello، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
6058
To page
6062
Abstract
A several series of low molecular weight 5-HT2A leads were identified from an analysis of HTS data, the exploration of SAR and optimization of one series using parallel synthesis are described, affording compound 22 (5-HT2A IC50 1.1 nM).
Keywords
5HT2A , Antagonist , library , High-throughput , screening , synthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797527
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