Title of article :
New pyrimido[5,4-b]indoles and [1]benzothieno[3,2-d]pyrimidines: High affinity ligands for the α1-adrenoceptor subtypes
Author/Authors :
Giuseppe Romeo، نويسنده , , Luisa Materia، نويسنده , , Gabriella Marucci، نويسنده , , Maria Modica، نويسنده , , Valeria Pittalà، نويسنده , , Loredana Salerno، نويسنده , , Maria Angela Siracusa، نويسنده , , Michela Buccioni، نويسنده , , Piero Angeli، نويسنده , , Kenneth P. Minneman، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
A number of new pyrimido[5,4-b]indole and [1]benzothieno[3,2-d]pyrimidine derivatives were synthesized and evaluated for their binding and functional properties at α1-adrenergic receptor (α1-AR) subtypes. They behaved as potent α1-AR antagonists. In binding experiments, some of them (RC24 and RC23) showed very high affinity for the α1D-AR subtype.
Keywords :
?1-Adrenoceptor , ligand , Antagonist , ?1D-Adrenoceptor subtype , synthesis
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
