Title of article
Isobrassinin and its analogues: Novel types of antiproliferative agents
Author/Authors
Péter Csom?s، نويسنده , , Istv?n Zupk?، نويسنده , , Borb?la Réthy، نويسنده , , Lajos Fodor، نويسنده , , George Falkay، نويسنده , , G?bor Bern?th، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
6273
To page
6276
Abstract
Isobrassinin (2-(S-methyldithiocarbamoylaminomethyl)indole (7a), a regioisomer of the cruciferous phytoalexin brassinin (1), exerted marked antiproliferative effects on the HeLa, A431 and MCF7 cell lines (>78.6% inhibition at 30 μM). For structure–activity relationships, further analogues were synthesized. The highest cytotoxic effect was displayed by 2-phenylimino-1,3-thiazino[5,6-b]indole (10) (10 μM, 76.8%—HeLa and 46.3%—MCF7). The effect of the natural phytoalexin brassinin was also determined.
Keywords
2-Aminomethylindole , 6-b]indole , antitumour activity , Dithiocarbamate
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797568
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