Author/Authors :
James C. Lanter، نويسنده , , James J. Fiordeliso، نويسنده , , Weiqin Jiang، نويسنده , , George F. Allan، نويسنده , , Muh Tsann Lai، نويسنده , , Olivia Linton، نويسنده , , Do Won Hahn، نويسنده , , Scott G. Lundeen، نويسنده , , Zhihua Sui، نويسنده ,
Abstract :
A series of novel 2-(1H-indol-2-yl)-propan-2-ols have been designed, synthesized, and screened for their ability to inhibit testosterone-induced prostate weight increases in immature rats. Through the use of this paradigm, we were able to identify compounds that exhibited in vivo potency equal to that of the marketed antiandrogen Casodex® when orally administered.
