Author/Authors :
Venkat R. Gadhachanda، نويسنده , , Baogen Wu، نويسنده , , Zhiwei Wang، نويسنده , , Kelli L. Kuhen، نويسنده , , Jeremy Caldwell، نويسنده , , Helmut Zondler، نويسنده , , Harald Walter، نويسنده , , Mark Havenhand، نويسنده , , Yun He، نويسنده ,
Abstract :
A series of 4-aminopyrimidines (1) was identified as novel HIV inhibitors of unknown molecular target. Structural modifications were carried out to establish its SAR and identify the linking site for target identification. A number of analogs were found to possess single digit inhibitory activity for HIV replication. Several analogs with various potential linkers, including a biotinated analog, also exhibited excellent potency, and could serve as tools for the identification of novel anti-HIV targets.
