Title of article
Nitrogen-containing flavonoids as CDK1/Cyclin B inhibitors: Design, synthesis, and biological evaluation
Author/Authors
Tao Liu، نويسنده , , Zhongmiao Xu، نويسنده , , Qiaojun He، نويسنده , , Yanhong Chen، نويسنده , , Bo Yang، نويسنده , , Yongzhou Hu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
278
To page
281
Abstract
A novel series of nitrogen-containing flavonoids 5a–l, 6a,b, and 7a,b were designed and synthesized as cyclin-dependent kinases (CDKs) inhibitors. The representative compounds 5a, 5b, 5e, and 5g showed potent CDK1/Cyclin B inhibitory activities. All compounds displayed a significant growth inhibitory action in vitro against Bel-7402, PC-3, ECA-109, A-549, HL-60, and MCF-7 cancer cell lines. Flow cytometry analysis showed that 5b induced apoptosis in PC-3 cells.
Keywords
Apoptosis , antiproliferative activity , flavonoids , Cyclin-dependent kinases (CDKs) inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797641
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