Title of article
Simplified staurosporine analogs as potent JAK3 inhibitors
Author/Authors
Shyh-Ming Yang، نويسنده , , Ravi Malaviya، نويسنده , , Lawrence J. Wilson، نويسنده , , Rochelle Argentieri، نويسنده , , Xin Chen، نويسنده , , Cangming Yang، نويسنده , , Bingbing Wang، نويسنده , , Druie Cavender، نويسنده , , William V. Murray، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
326
To page
331
Abstract
Simplification of bottom ring and regioselective functionalization of the indolocarbazole unit of staurosporine (2) are described. The modification led to a new series of simplified staurosporine analogs, which exhibited significant inhibitory activity against Janus kinase 3 (JAK3). The structure–activity relationships (SAR) are discussed and a proposed binding model is also highlighted.
Keywords
Janus kinases 3 , Jak3 , Staurosporine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797648
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