Title of article
New carbon-linked azole oxazolidinones with improved potency and pharmacokinetics
Author/Authors
Sheila I. Hauck، نويسنده , , Christer Cederberg، نويسنده , , Amanda Doucette، نويسنده , , Lena Grosser، نويسنده , , Neil J. Hales، نويسنده , , Grace Poon، نويسنده , , Michael B. Gravestock، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
337
To page
340
Abstract
Substitution of phenyl oxazolidinones with carbon-linked azoles resulted in the discovery of a new class of potent oxazolidinones that have excellent Gram-positive activity. In addition, replacement of the C-5 acetamide side chains with a 4-methyl triazole diminished monoamine oxidase activity. The synthesis and biological evaluation of these compounds are reported.
Keywords
Triazoles , Oxazolidionones , isoxazoles
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797650
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