Title of article
From dihydroxypyrimidine carboxylic acids to carboxamide HIV-1 integrase inhibitors: SAR around the amide moiety
Author/Authors
Alessia Petrocchi، نويسنده , , Uwe Koch، نويسنده , , Victor G. Matassa، نويسنده , , Barbara Pacini، نويسنده , , Kara A. Stillmock، نويسنده , , Vincenzo Summa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
350
To page
353
Abstract
4,5-Dihyroxypyrimidine carboxamides, which evolved from a related series of HCV NS5b polymerase inhibitors, have been optimized to provide selective HIV integrase strand transfer inhibitors. Extensive SAR around the benzylamide moiety led to the identification of the p-fluorobenzylamide as optimal in the enzymatic assay.
Keywords
HIV integrase inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797653
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