Title of article :
New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase
Author/Authors :
Matthieu Fonvielle، نويسنده , , Helene Therisod، نويسنده , , Marion Hemery، نويسنده , , Michel Therisod، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
We report the synthesis and biochemical evaluation of new competitive inhibitors of the cytosolic (NADH-dependent) glycerophosphate dehydrogenase. The best tested compound, phosphono-propionohydroxamic acid, with a Ki of 6 μM, might be of interest as an anti-obesity drug.
Keywords :
Triglycerides Metabolism , Organic phosphonates , Enzymes inhibitors , hydroxamic acids , Glycerophosphate dehydrogenase , anti-obesity drugs
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
