Title of article
New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase
Author/Authors
Matthieu Fonvielle، نويسنده , , Helene Therisod، نويسنده , , Marion Hemery، نويسنده , , Michel Therisod، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
410
To page
413
Abstract
We report the synthesis and biochemical evaluation of new competitive inhibitors of the cytosolic (NADH-dependent) glycerophosphate dehydrogenase. The best tested compound, phosphono-propionohydroxamic acid, with a Ki of 6 μM, might be of interest as an anti-obesity drug.
Keywords
Triglycerides Metabolism , Organic phosphonates , Enzymes inhibitors , hydroxamic acids , Glycerophosphate dehydrogenase , anti-obesity drugs
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797665
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