Title of article
Hemodynamic effects of potent and selective JNK inhibitors in anesthetized rats: Implication for targeting protein kinases in metabolic diseases
Author/Authors
Gang Liu، نويسنده , , Baolin Wu&Hongyu Zhao، نويسنده , , Bo Liu، نويسنده , , Zhili Xin، نويسنده , , Mei Liu، نويسنده , , Michael D. Serby، نويسنده , , Nathan L. Lubbers، نويسنده , , Deborah L. Widomski، نويسنده , , James S. Polakowski، نويسنده , , David W.A. Beno، نويسنده , , James M. Trevillyan، نويسنده , , Hing L. Sham، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
495
To page
500
Abstract
The hemodynamic effects of a series of potent and selective 4-aminopyridine carboxamide-based pan-JNK inhibitors were assessed in an anesthetized rat model. The effects of these agents on mean arterial pressure, heart rate, cardiac contractility, and peripheral vascular resistance are described, and the implication for targeting protein kinases in metabolic diseases is discussed.
Keywords
c-Jun N-terminal kinase inhibitor , Anesthetized rat model , cardiotoxicity , Metabolic diseases
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797683
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