Author/Authors :
Gang Liu، نويسنده , , Baolin Wu&Hongyu Zhao، نويسنده , , Bo Liu، نويسنده , , Zhili Xin، نويسنده , , Mei Liu، نويسنده , , Michael D. Serby، نويسنده , , Nathan L. Lubbers، نويسنده , , Deborah L. Widomski، نويسنده , , James S. Polakowski، نويسنده , , David W.A. Beno، نويسنده , , James M. Trevillyan، نويسنده , , Hing L. Sham، نويسنده ,
Abstract :
The hemodynamic effects of a series of potent and selective 4-aminopyridine carboxamide-based pan-JNK inhibitors were assessed in an anesthetized rat model. The effects of these agents on mean arterial pressure, heart rate, cardiac contractility, and peripheral vascular resistance are described, and the implication for targeting protein kinases in metabolic diseases is discussed.
Keywords :
c-Jun N-terminal kinase inhibitor , Anesthetized rat model , cardiotoxicity , Metabolic diseases
