Author/Authors :
Gilles D. Tamagnan، نويسنده , , Eric Brenner، نويسنده , , David Alagille، نويسنده , , Julie K. Staley، نويسنده , , Colin Haile، نويسنده , , Andrei Koren، نويسنده , , Michelle Early، نويسنده , , Ronald M. Baldwin، نويسنده , , Frank I. Tarazi، نويسنده , , Ross J. Baldessarini، نويسنده , , Nachwa Jarkas، نويسنده , , Mark M. Goodman، نويسنده , , John P. Seibyl، نويسنده ,
Abstract :
A series of reboxetine analogs was synthesized and evaluated for in vitro binding as racemic mixtures. The best candidate (INER) was synthesized as the optically pure (S,S) enantiomer, labeled with iodine-123 and its in vivo binding determined by SPECT imaging in baboons. The in vivo specificity, selectivity, and kinetics of [123I]INER make it a promising agent for imaging NET in vivo by noninvasive SPECT imaging.
Keywords :
SPECT , Norepinephrine , reboxetine , iodine-123 , Transporter , imaging
