Title of article
Synthesis and antimalarial activity of new 1,12-bis(N,N′-acetamidinyl)dodecane derivatives
Author/Authors
Mahama Ouattara، نويسنده , , Sharon Wein، نويسنده , , Michèle Calas، نويسنده , , Yen Vo Hoang، نويسنده , , Henri Vial، نويسنده , , Roger Escale، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
593
To page
596
Abstract
Amidoxime and O-substituted derivatives of the bis-alkylamidine 1,12-bis(N,N′-acetamidinyl)dodecane were synthesized and evaluated as in vitro and in vivo antimalarial prodrugs. The bis-O-methylsulfonylamidoxime 8 and the bis-oxadiazolone 9 derivatives show relatively potent antimalarial activity after oral administration.
Keywords
Antimalarial agents , Bis-alkylamidine , Bis-alkylamidoxime , O-substituted bis-alkylamidoxime , prodrugs
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797700
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