Title of article :
Core exploration in optimization of chemokine receptor CCR4 antagonists
Author/Authors :
Ashok V. Purandare، نويسنده , , Honghe Wan، نويسنده , , John E. Somerville، نويسنده , , Christine Burke، نويسنده , , Wayne Vaccaro، نويسنده , , Xiaoxia Yang، نويسنده , , Kim W. McIntyre، نويسنده , , Michael A. Poss، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
The design, synthesis, and SAR studies of ‘core’ variations led to identification of novel, selective, and potent small molecule antagonist (22) of the CC chemokine receptor-4 (CCR4) with improved in vitro activity and liability profile. Compound 22 was efficacious in a murine allergic inflammation model (ED50 10 mg/kg).
Keywords :
Antagonist , asthma , mDC , TARC , Chemokine receptor CCR4 , atopic dermatitis
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
