Title of article
Core exploration in optimization of chemokine receptor CCR4 antagonists
Author/Authors
Ashok V. Purandare، نويسنده , , Honghe Wan، نويسنده , , John E. Somerville، نويسنده , , Christine Burke، نويسنده , , Wayne Vaccaro، نويسنده , , Xiaoxia Yang، نويسنده , , Kim W. McIntyre، نويسنده , , Michael A. Poss، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
679
To page
682
Abstract
The design, synthesis, and SAR studies of ‘core’ variations led to identification of novel, selective, and potent small molecule antagonist (22) of the CC chemokine receptor-4 (CCR4) with improved in vitro activity and liability profile. Compound 22 was efficacious in a murine allergic inflammation model (ED50 10 mg/kg).
Keywords
Antagonist , asthma , mDC , TARC , Chemokine receptor CCR4 , atopic dermatitis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797718
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