Title of article
Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore
Author/Authors
John M. Keith، نويسنده , , Leslie A. Gomez، نويسنده , , Michael A. Letavic، نويسنده , , Kiev S. Ly، نويسنده , , Jill A. Jablonowski، نويسنده , , Mark Seierstad، نويسنده , , Ann J. Barbier، نويسنده , , Sandy J. Wilson، نويسنده , , Jamin D. Boggs، نويسنده , , Ian C. Fraser، نويسنده , , Curt Mazur، نويسنده , , Timothy W. Lovenberg، نويسنده , , Nicholas I. Carruthers، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
702
To page
706
Abstract
A series of tetrahydroisoquinolines acting as dual histamine H3/serotonin transporter ligands is described. A highly regio-selective synthesis of the tetrahydroisoquinoline core involving acid mediated ring-closure of an acetophenone intermediate followed by reduction with NaCNBH3 was developed. In vitro and in vivo data are discussed.
Keywords
Histamine H3 , 5-HTP potentiation , serotonin transporter , ring-closure
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797723
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